Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
نویسندگان
چکیده
منابع مشابه
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo.
Cerebral insulin receptors play an important role in regulation of energy homeostasis and development of neurodegeneration. Accordingly, type 2 diabetes characterized by insulin resistance is associated with an increased risk of developing Alzheimer's disease. Formation of neurofibrillary tangles, which contain hyperphosphorylated tau, represents a key step in the pathogenesis of neurodegenerat...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2005
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.54.12.3343